Ada Twist Scientist

Amanda Christine
as Ada Twist

Kaya Jackson
as Ada Twist

Nicholas Crovetti
as Iggy Peck

Candace Kozak
as Rosie Revere

Terrence Little Gardenhigh
as Arthur Twist

Susan Kelechi Watson
as Mom Twist

Taye Diggs
as Dad Twist

Corey J. Laramore
as Benny B

Fortune Feimster
as Rosie

Paul F. Tompkins
as Iggy

Margo Martindale
as Great Aunt Rose

Loretta Devine
as Great Aunt Bernice

Yonas Kibreab
as Miguel

Mykal-Michelle Harris
as London

Kate Micucci
as Iggy

Táta Vega
as Eleanor

Carolyn Hennesy
as Marian

Krizia Bajos
as B.R.I.

Dashiell McGaha-Schletter
as Simon

Alex Jayne Go
as Sawa

Ali Wong
as Cherry Chen

Lyriq Bent
as Beck

Nia Madison Thompson
as Bee-Bee

Nicole Byer
as Professor Flowerbomb

George Takei
as Sensei Dave